Essentially it depends on your purpose. If there is a molecular tumor board in the center where you are treated and if your results will be evaluated by an experienced team, the best decision would be comprehensive genomic profiling. In other words, comprehensive genomic profiling tests are scientifically proven to be accurate, and every spot of more than 300 genes is analyzed.
However, if these facilities are not available, or at the discretion of you or your physician, treatment decisions can be made with narrower tests. Mutations detected by these tests are also important in personalized treatment. However, if mutations cannot be detected with these tests, this does not mean that you are not suitable for personalized treatment. It is not true to say that there is no gene detected and I am not suitable for this approach. It means that there is no mutation in the analyzed gene regions. Cancer does not develop without mutation, there must have been a difference that cancer developed. In this case, comprehensive genomic analyzes should be performed.
In addition, price differences between these tests and whether they are within the scope of reimbursement institutions also show differences.