Hypertermia

 

By genetically analyzing the cancer, the treatment should be designed by revealing the changing biology in cancer. Not all cancer cells are the same, but rather different. Think of it like snowflakes, we call them all snow, but when you look closely, each snowflake is different, and so are the cancer cells. We call them all cancers, but we mean an infinite number of altered cell communities. Therefore, cancer treatment should be done not with a single drug or method, but with combinations, and it will be. We'll be more successful as long as we can join forces.

 

 

It is possible to extend this list. However, it should be noted that all methods and approaches needs to be brought together attentively. In  our clinic, which is a pioneer in both personalized cancer center and  integrative treatment methods, all methods that can touch the lives of our patients are applied.

Heat treatments are the methods that have been used for centuries. Baths,  heat tents and similar euphemists of Indians are the treatments used in traditional medicine. Today,  we hear the  name of hyperthermia too much. Now his name is frequently mentioned in scientific articles. Hyperthermia, which is also used intensively  in cancer patients, has also gained a place in the modern medical literature as a form of treatment in which has achieved serious success. 

In history, there are many documents to reveal the utilization of increasing the body temperature for the treatment of various diseases. Parmenides, one of the natural philosophers, said, "Give me the opportunity to increase the temperature of the body and I will cure all diseases." For this reason, doctors dealing with hyperthermia are sometimes  called Permenian doctors.

For thousands of years, mankind has thought that some diseases can be cured by increasing body temperature. It is known that our immune system is better stimulated by the increase in heat. When body temperature increases, your lymphocytes, neutrophils; in other words, your immune system's ability to fight and move increases much more.

The structures of cancer cells are different from normal cells. The first time was in the late 1800s, when Mr.  Coley had an interesting gig while he was the Chief Physician of New York Cancer Hospital. He found that in cancer patients with infections, the size of the tumor had declined and they lived longer. And so he noticed  this in Erizipelli (disease) patients and used the link between fever, infection and cancer. He then  made a special solution of these infected materials  obtained  from the patients. Coley injected this solution, which we call the toxin, into tumor tissue of the patients. When we evaluate this study with our current knowledge, we can see that Mr. Coley both performs immunotherapy and injects a different antigen into the tumor.

As a result, he had a fever due to the toxin injection; thus, it has increased the body's ability to fight and has achieved much more successful results in patients who have had this application. One of these patients is Zola. Zola recovered completely with this treatment. The person who enabled her to be successfully treated with this study was Mr. It's Coley. Since then, the relationship between fever and cancer has always attracted attention.

After the development of chemotherapies in the 1960s, a problem was observed in the delivery of chemotherapies to cancer cells. This disruption in the use of chemotherapy agents has revealed structural differences in cancer cells. At this point, let's answer 3 important questions together:

How is it different from normal?

What is cancer? 

Our normal cells can use sugar, fat and certain proteins as nutrients. These go into the cell. While fats and proteins can be burned directly in mitochondria, our energy factory, sugar is a 6-carbon compound.  This 6-carbon compound enters  the heat of the mound and then falls into 2-3 carbon compounds. This is called fermentation or glycolysis by its medical name. These 2-3 carbon molecules are then re-trained in the energy plant mitochondria for burning, where they are burned with oxygen. Water and carbon dioxide come out of the cell. We take oxygen, we give carbon dioxide; water is already the requirement of our body, and more is excreted by urine. It's a way of getting energy. In other words, mankind is an entity that is fueled by carbon-based fuel.

If somehow the cells have to be fed only glucose before they can reach oxygen, or if they have a mutation and go down this path, they have to use only sugar. Normally, when we burn with oxygen, we get 38 ATP units of energy from 1 molecule of glucose. But if you don't use oxygen (if you don't use mitochondria), you can get only 2 units of ATP out of 1 mole glucose. So it only causes fermentation.

To  give you a squeal,  what does 'cramping' mean? When not enough oxygen can go to a certain point in the body, the cell receives glucose, burns it with fermentation and obtains 2 units of energy. This time, acid comes out of the cell instead of carbon dioxide and water. Wherever the cramp went, it is the  lactic acid that causes that pain. It's  also called  fatigue acid.

When you metabolically look at the cancer cell, here's how to explain why it consumes only sugar about 200 times that of a normal cell:

Cancer cells obtains 2 units of energy from 1 sugar. They should use a lot of sugar so that they can provide his energy; to survive. Energy consummation of a cancer cell is 200 times the energy of a normal cell. And only acid comes out of the potion, where it doesn't use mitochondria. It doesn't need oxygen. So how does he carry all this sugar to himself? It provides logistics by making a lot of new veins. It is just a sugar-fed cell that doesn't need oxygen and constantly throws acid out of the cell, and a cell that's made a lot of new veins. With a sea of acid around it, you're dealing with a cell that's adapted to that environment.  The  tumor cell goes to other organs with blood vessels that it makes without the need for oxygen. A cancer cell can meet your sugar needs even if you don't eat sugar. That's where the problem begins...

The cell wall structure of the cell, which constantly throws acid out, is also different. Therefore, if any drug given cannot be entered into the cell; this acid environment should be passed, then it should be passed through the wall of the cell and enter the interior of the cell.  This is where the  euphoria of hyperthermia begins. The thick fatty wall of the cancer cell is the defense mechanism developed by the tumor to withstand the acidic environment. If the environment in which the tumor is heated, the cell wall begins to melt. Thanks to the melting cell wall, the defence of the cell wall is disturbed.

 

 

Radiotherapy and Chemotherapy Application with Hyperthermia

Chemotherapy, radiotherapy and hyperthermia are complementary treatments. When the permeability of the cell wall fails,

1. The tumor cell begins to be affected by acid
2. The given medicines penetrate into the tumor.
3. As the vessels expand, more drugs penetrate into the cell.
4. All DNA damage is repaired immediately by DNA Polymerizes. However, these are the enzymes most sensitive to heat, which are disabled by hyperthermia. When these are disabled, the damage you inflict on cancer cells is permanent. In other words, hyperthermia increases the effectiveness of both chemotherapy and radiotherapy by approximately 2-5 times when used in combination.

Radiotherapy, Chemotherapy and Vitamin C Application with Hyperthermia

In the treatment of a tumor, whatever success you have achieved in your first hit is the best. You have much less chance of succeeding that big on the next try. For this reason, a goal-oriented, anti-cancer strategy should be set from the beginning by making an analysis before starting the treatment. These issues should be discussed with the patient from the very beginning and the strategy to be applied at which stage should be explained.

For example, is the patient's tumor burden high? Then do you give chemotherapy or radiotherapy or both together with Vitamin C and hyperthermia all together to reduce the tumor burden first? What are your plans after reducing the tumor burden? Are you planning surgery or immunotherapy? Have another approach? The roadmap should always be shared with the patient. There is no such option as trial and error in cancer treatment. The treatment process is a multi-disciplinary journey that requires reorganizing the life of a cancer patient, and for this reason, the right planning for the issues that will affect the behavior and psychology of the patient should be made specific to the patient from the very beginning.

Vitamin C and hyperthermia are used together with it to increase the effect of chemotherapy and to achieve an effective treatment and a better quality of life. Vitamin C and hyperthermia alone are not recommended in the treatment of cancer.

Local hyperthermia is given  immediately after radiotherapy treatment in lung patients and cervical diseases. In this way, the effect of radiotherapy and the effect of chemotherapy increases about 2-5 times; hyperthermia opens the way to a more successful treatment. Hyperthermia, which is applied by a specialists with serious knowledge, has almost no side effects, as long as the most appropriate treatment is determined by performing personal analyses and examinations related to the patient.

How Many Types of Hyperthermia Applications Are There?

Hyperthermia can be used in any tumor. You can see tumors in MRI even though their magnetic fields and electrical properties are different; in the same way, hyperthermia is effective due to the common characteristics of tumors of different regions.

Hyperthermia is divided into 2 main groups. First, whole body hyperthermia; a form of treatment that results from heating the whole body… Secondly, local hyperthermia; the treatment method applied only to the tumor area.

Local Hyperthermia is especially effective with radiotherapy and chemotherapy. Local Hyperthermia is applied  with radiotherapy  in tumors such as lungs and cervix. In the applications together, it is  recommended to take local hyperthermia for 1-2 hours after radiotherapy.  However, it can also be applied to the conditions for up to 4 hours.

Local hyperthermia is recommended first, followed by radiotherapy, in other tissues except the brain. Timings of chemotherapy agents may vary depending on the agent. However, it is not applied to the brain, especially with radiotherapy, but it can be applied together with chemotherapy. The aim here is not to increase the temperature of the brain with Hyperthermia. In brain tumors, the aim is to benefit from the electromagnetic field effect created by Hyperthermia.

 

Celsius42 TCS systems are used as local hyperthermia in our clinic

 

In this regard, Dr. Hüseyin Şahinbaş,  who lives in Germany, has a  lot of successful studies  on children  and has published. Today, new systems that can be carried on patients continuously and effective in brain diseases with portable, electrical mechanisms are also being developed and approved by the FDA.

 In which types of tumors hyperthermia can be used?

Tumors are divided into 2 main groups.

1. Solid tumors: arising from organs

2. Originating from blood cells

Hyperthermia can be used in solid tumors. It is not yet used in leukemia patients.

Hyperthermia Use in Healthy People

Local hyperthermia does not apply to healthy people. But an important part of physical therapy is heat therapy. Diathermy devices are already used in physical therapy; they also move in the presence of heat and radio frequency waves. Of course, the features of the devices used in cancer and those used in physical therapy are different. However, when whole body hyperthermia is mentioned, it is possible to talk about a completely different mechanism.

The whole body Hyperthermia is divided into 4 main groups:

1. Thermal Treatment: It is aimed to increase the body temperature above 44 degrees. This is a treatment method mostly used in viral diseases such as AIDS.

2. Extreme Hyperthermia: It is aimed to increase the temperature of the body above 42 degrees. Here, in local hyperthermia, we increase the temperature of tumor cells to 42 degrees, and it is a method used in cancer treatment with the logic of increasing the temperature of the whole body above 42 degrees.

3. Fever Range Hyperthermia: It is a method of hyperthermia called fever-like. A maximum of 39.5-40, 40.5 degrees is reached; The target is not high.

4. Moderate Hyperthermia: It is aimed to increase the body temperature to 38.5 degrees.

Number 4 hyperthermia variant is not for oncological purposes; are heat increasing methods used in other subjects. Thermal therapy and extreme hyperthermia require intensive care conditions and a very serious experience. However, there is no need for intensive care conditions in fever-like hyperthermia and moderately mild hyperthermia applications called "fever range". Extreme hyperthermia and thermal therapy are not applied in Turkey. Applied in Turkey, called fire-like; In other words, they are the methods that aim to increase the body temperature up to 40 degrees and 40.5 degrees. Usually, 39.5 degrees is sufficient. The aim here is to activate the immune system.

Moreover, 24 hours after chemotherapy, when whole body hyperemia is applied, your body temperature and blood circulation increase. Sweating begins and very serious chemotherapy toxins are excreted together with sweat. Thanks to hyperthermia, patients can spend a comfortable time after chemotherapy.

A second point is that after chemotherapy has damaged the cancer cell, the antigens of the tumor are released. Since the immune system is activated by the hyperthermia of the whole body, which you do 24 hours after chemotherapy, the immune system begins to recognize tumor antigens that it cannot distinguish from normal cells. Studies conducted at the University of Texas show that better results can be obtained when you reduce the chemotherapy dose up to 30% and perform whole body hyperthermia the next day; There is also evidence that even better results can be obtained from full-dose chemotherapy.

Whole body hyperthermia is used  in myositis, muscle diseases, depression, chronic inflammatory diseases, intestinal diseases, ulcerative colitis in a number of areas. In particular, it  is one of the most effective treatments for Lyme disease. 

The homeland of hyperthermia is Germany. The devices used in hyperthermia are German made. Health tourism related to Lyme disease is very developed in Germany. There are health centers that apply hyperthermia to 3-4 patients a day. There is no reason why it should not develop in our country. If you look at the lists of social security Institution and private health insurances, you will see that hyperthermia treatment is on the payment list. However, there is not enough knowledge and experience on this subject in our country yet. People prefer to reject the subject they do not know. However, Hyperthermia is a treatment that is applied in all countries from Japan to America, from Germany to Switzerland, Greece and Mexico. And in the insurance system in America and Japan, treatment costs are reimbursed to patients.

Science Learned from Patients?

Science or medicine should not only consist of applying what is written in the book. Develops science. Science is a phenomenon that needs to be produced and developed. Medicine, too, should not be a profession consisting of applying the best of what is written in the prospectuses of pharmaceutical companies. Patients can be more researchers than physicians, as they experience the problems they live and may experience individually. What more can be done, what are the options, what are the innovations, they are in a constant effort to find solutions. Physicians, beyond being understanding, can find the opportunity to learn an innovation or idea that they have overlooked, if they can evaluate the information that may come their way. If the aim is to put science at the service of the patient for health, it can easily be said that the luxury of ignoring knowledge belongs to no one.

Relationship Between Heat and Disease

The main purpose of increasing body temperature is to regulate the immune system and ensure that the system works better.

According to a study, it was noticed that in children who used antipyretics when they got sick, their immune systems work worse, and some diseases are more common in later ages. In our society, there are beliefs such as if fever rises, seizures, epilepsy, epilepsy will occur. In fact, keeping the fever a little high will provide a faster and faster recovery.

When heat is used on diseased areas, it is one of our most important auxiliary treatments both in physical therapy in muscles and in cancer treatment. When used correctly, it has a positive effect on human health. For thousands of years, humanity has used heat and, by developing special devices, it is obvious that if the body is being warmed up and some tissues, especially tumor tissues, are being worked on, it should be spread more in the name of the knowledge and service to the patients.

APPLYING LOCAL HYSTERIA

After the patient makes the decision of local hyperthermia, it can also be applied with chemotherapy and radiotherapy. After registering the patient's information and data in the system,  it is immediately determined how to  apply hyperthermia.

 

 

For example, this is our 5-inch upper electrode. This is our head electrode... Likewise, we have 15 cm lower and 25 cm lower electrodes. At one point deep, two equal electrodes are used, and if it is closer to one side, a small electrode is used on the near side.

Example:

The big electrode at the bottom is 25cm.  but if the patient's lesion is in the neck, it is also 15 cm to the neck brace, which is close to the whole.  When the electrode is inserted, the energy is intensified by the system with the smaller electrode. If the lesion is deeper, for example in the lung, two equal electrodes are used. In this way, the way of treatment can be adjusted to the kidneys that are close or far from the whole.

Usually, the initial application time is set to 20 minutes. This is due to both increased blood supply in the  tissue and adaptation of the tissue. Once the system, energy and time are determined, the data entered from the computer is transferred to the device when it is ready.

In the device, the data, the energies given, if the system we give is correct, after confirming, the treatment of the patient's diseased kidney is started. There should be nothing left between  the skin and the electrode in the patient's appropriate treatment. Only a deionized water bag is placed to ensure full contact between the  skin and  electrode. The upper electrode is then confirmed to be right on top of the lower electrode. After hearing the first "click" sound, the device requests confirmation a second time. And the treatment is initiated. The system controls it, and when the light is on, the device begins to give energy to the area where it is located through electrodes.

You can also check that the energy is generated in the patient. 13.56 Megahertz radiofrequency wave create an energy field on  this page and above the patient.  The lamp with powder fluorescence also burns at 13.56 Megahertz. After starting to take the energy from the patient, the lamp begins to light up. When you approach this system, which passes through the patient's second and creates an energy field around it, the lamp that lights up spontaneously when you go out of the area.

The energy field will not expand as the time remaining on the device increases. However, when you increase the energy in the system, it may expand a little more, but usually the freckle from the patient does not come around. The area where the basic energy is collected is the targeted bug of the whole.

With hyperthermia we are talking about heat. However, patients say that they feel an extreme cold in the area where hyperthermia is given. Since the target is to heat the deep tissue, fatty tissues absorb some energy. Therefore, there is a very special cooling system under the electrodes in the system. The system provides continuous cooling in order to ensure that the energy can go to the denser lower tissues without cooling the skin and absorbing the energy, and to prevent the skin from burning. Most of the noise the device makes is caused by the cooling system. By adjusting the surface cooling degree according to the patient, the areas where the electrode is located from both the lower and upper sides, it is ensured that all of the energy can be transmitted to the inner region in a comfortable way.

Cooling is not used while performing these tasks in more superficial tumors. Then, it can be changed with the heat, and the cooling temperature can be changed and it can be effected more quickly. 

ATTENTION!

Hyperthermia is not an operation related to medical aesthetics. The hyperthermia device is a treatment device for cancer. It is not used for fat melting. Local Hyperthermia is never applied alone. It is definitely applied as a part of the cancer treatment determined by your doctor. Timings are also very important, especially after radiotherapy, according to the type of chemotherapy drug. Once all the variables have been determined, hyperthermia is also adapted into the patient's treatment scheme to achieve a more effective and more successful outcome.

WHOLE BODY HYPERTHERMIA APPLICATION

 

 

Heckel HT3000 Hyperthermia systems are used in our clinic (https://www.heckel-hyperthermia.com).

Major Areas of All Body Hyperthermation;

• With Oncological Treatments, As Part of Cancer Treatment
• Fibromyalgia, Chronic Painful Diseases of the Skeletal System
• Chronic inflammatory diseases (such as psoriasis, Neurodermitis, ankylosing spondylitis, asthma)
• Chronic Infections, Lyme Disease
• Depression

We classified whole body hyperthermia as thermal therapy, extreme whole body hyperthermia, whole body hyperthermia, which we call fever-like 'fever range', and mild to moderate hyperthermia. Whole body hyperthermia can be done both to strengthen the immune system and to benefit from the detox effect.

The whole body of our patient is taken into the device, with the head out. Here, a system that produces 4 ultraviolet nets, that is, imitates the ultraviolet net of sunlight, is used and the chest area is targeted. Because the place where the veins are closest is the chest area. Since the heat goes down to 2 cm deep, the veins there are heated. All the parameters of the patient, the patient's body temperature, blood pressure, pulse, respiratory rate, oxygenation status, especially the internal temperature is monitored ontinuously. On the lower side, there is a system that provides the heat circulation inside and works to warm the body equally. If the patient has had whole body hyperthermia before, the data there can be opened at the same time and a comparison can be made between the two.

The aim is to increase the body temperature up to 38.5 or even 39, where the immune system works best. However, the body has a resistance to raising the temperature. So, you might think that you don't want to work. You would see that people did not have a fever even though they were infected. At this point, think of Hyperthermia as a kind of exercise, a training. With each hyperthermia treatment, body temperature begins to rise faster. There  are 2 purposes of the treatment of moderate-mild hyperthermia and what we call  the heat-like 'fever range'. It is important to strengthen the immune system and  take advantage of the detox effect. Cancer survivors should also keep their immune system active after the treatments they receive.

But for cancer patients, the "fever range" heat-like hyperthermia is usually performed 24 hours after chemotherapy. There are two purposes to this. The first 24 hours of chemotherapy are the main effect of the treatment. When you do this the next day,  especially after the fever rises above 38.5 degrees, patients  sweat the squat severely. Sweating is an euphoric detox method, and toxins in the body are excreted in this way. The first goal is to eliminate the toxins of chemotherapy  from the body thanks to hyperthermia. Sweat excreted by hyperthermia leaves a strange smell in the room. Squeeze that sweat  at the bottom of a flower, you can see that the flower is dry and broken.

The second effect is to ensure that the immune system is active when you rise above  38.5. One day, you give the patient chemotherapy, the damage that chemotherapy causes in the whole world, the antigens of the whole country, the different proteins of the whole euphemism. By stimulating the immune system the next day, you support him to be active and attack all the food  while allowing him to recognize these antigens.

As the body temperature rises, blood circulation increases, his pulse rises, and oxygen penetration to all tissues is  increased. Oxygen is cancer's favorite element. Oxygenation is also increased, and the patient is given oxygen during the treatment. After the entire body ends hyperthermia, blood circulation returns to normal. However, it does not return to normal in all its cells. This feature also provides an advantage in radiotherapy. For example, in the morning, the protocols for applying all-body hyperthermia and radiotherapy treatments were started to be developed. Because in the treatment of radiotherapy, the more blood there is in the target area, the more oxygen there is, the better it is possible to get results.

With all-body hyperthermia after chemotherapy, patients undergo a more comfortable chemotherapy deed. Liquid on one side of the body after the excretion of toxins; on the one hand, Vitamin C is given. There are fewer side effects such as nausea and vomiting. However, all body hyperthermia treatment can be done in a long time as 4-5 hours. For this reason, a maximum of 2 patients can be admitted to a device per day.